Shire Plc
SHP:LN

Appointed: September 1, 2011 Committee membership: Nomination Committee Susan served as an independent Non-Executive Director prior to her appointment as Chairman on April 29, 2014. Skills & experience: Susan brings to her role extensive M&A and finance experience having enjoyed a distinguished global career in investment banking. She held senior positions with The First Boston Corporation, Bankers Trust, Barclays de Zoete Wedd and most recently Credit Suisse where she was Chairman of the EMEA Mergers & Acquisitions team until 2009 and a part-time senior advisor until 2014. Susan is also a former Director of L’Occitane International S.A. and Coca-Cola HBC AG. She holds a BA in Economics and a MBA. Key appointments: BBA Aviation plc (Non-Executive Director), Keurig Green Mountain, Inc. (Non-Executive Director) and Fortune Brands Home & Security, Inc. (Non-Executive Director).

Committee Chairmanship: Executive Committee Flemming served as Chief Executive Officer Designate prior to his appointment as Chief Executive Officer on April 30, 2013. Skills & experience: Flemming brings to his role his operational and medical knowledge and his extensive international, strategic and operational experience in the pharmaceutical sector. He formerly held the position of Non-Executive Chairman of Evotec AG and was Non-Executive Director of PCI Biotech Holding ASA. From 2010 to 2012 he was Chief Marketing Officer and Global Head, Strategic Marketing for General and Speciality Medicine at Bayer. From 2008 to 2010 Flemming served as Global President, Pharmaceuticals and OTC at Bausch & Lomb, Inc. He also served as Chairman, and later as President and Chief Executive Officer, of Life-Cycle Pharma A/S from 2006 to 2008, and as President and Chief Executive Officer of Ikaria, Inc. from 2005 to 2006. Earlier in his pharmaceutical career Flemming held roles of increasing responsibility at Merck & Co., Inc. and Novartis AG, following a distinguished period spent in hospitals and academic medicine. Flemming received his MD from the University of Copenhagen, MBA from INSEAD and Master of Public Health from Harvard University.

Appointed: April 30, 2015 Committee Membership: Executive Committee Skills & experience: Jeffrey “Jeff” brings to the Board his financial, commercial and strategic acumen. Since joining Shire in 2003 he has held leadership positions in finance supporting the Neuroscience, Gastrointestinal and Rare Diseases business units as well as the positions of Interim Chief Financial Officer and Head of Investor Relations. In addition, Jeff oversaw the operations of the Rare Diseases business unit in North America, Latin America and Asia Pacific, as well as leading the integration of the legacy-Viropharma rare disease products into the Shire portfolio. Prior to joining Shire, Jeff spent time at Cinergy Corp. and PPG Industries in a variety of corporate finance and business development roles, in addition to serving as a commissioned officer in the U.S. Navy. He received a Bachelor of Arts in Economics from Duke University and a Master of Business Administration in Finance from the Kelly School of Business at Indiana University

Appointed: April 5, 2004 Committee Chairmanship: Nomination Committee Committee membership: Audit, Compliance & Risk Committee David was appointed Senior Independent Non-Executive Director in July 2007 and Deputy Chairman in June 2008. Skills & experience: David brings to the Board his extensive knowledge and experience in financial reporting, risk management and internal financial controls. He served on the Board of InterContinental Hotels Group plc until 2014, was Chairman of Premier Foods plc until 2010 and held directorships at Camelot Group plc and HMV Group plc. David retired from Cadbury Schweppes plc in 2004 after serving as Chief Financial Officer since 1995. He worked for the Cadbury Schweppes Group between 1965 and 1984 and rejoined the company in 1989 following its acquisition of the Trebor Group, where he was Financial Director. David is a Fellow of the Chartered Institute of Management Accountants. Key appointments: Flybe Group plc (Non-Executive Director).

Appointed: January 1, 2014 Committee Chairmanship: Audit, Compliance & Risk Committee Skills & experience: Dominic brings to the Board his strategic and financial experience. He holds the position of Group Finance Director at Compass Group PLC, having held the positions of Chief Financial Officer at Iglo Foods Group and European Finance & Strategy Director, Corporate Finance Director, and Group Financial Controller at Cadbury plc. Earlier in his career Dominic worked at PricewaterhouseCoopers where he advised pharmaceutical sector clients. Key appointments: Compass Group PLC (Group Finance Director).

Appointed: July 1, 2015 Committee membership: Science & Technology Committee Skills & experience: Olivier brings to the Board his extensive international business and leadership experience gained through roles held in pharmaceutical and healthcare companies across Europe, the Middle East and the US. He currently holds the position of Chief Executive Officer at Smith & Nephew plc, having previously served as Chief Executive Officer and President of Pierre Fabre Group and as President of Abbott Pharmaceuticals; a division of US-based Abbott Laboratories. Olivier has also held diverse commercial leadership positions at GlaxoSmithKline and its predecessor companies in France. He has an MBA from HEC Paris School of Management and a doctorate in Pharmacy from the University of Paris. Key appointments: Smith & Nephew plc (Chief Executive Officer) and Virbac SA (Non-Executive Director).

Appointed: March 15, 2010 Committee membership: Remuneration Committee, Nomination Committee and Science & Technology Committee Skills & experience: William “Bill” brings to the Board extensive international R&D, commercial, business development and operational experience in the pharmaceutical sector. He worked for Roche from 1986 until 2009; most recently holding the position of CEO of their pharmaceuticals division and serving as a member of the Roche Group Corporate Executive Committee. Bill holds a BA (Hons). Key appointments: Masters Pharmaceuticals (Chairman), Biotie Therapies Corp. (Chairman), Mesoblast Limited (Non-Executive Director), Vestergaard Frandsen (Vice Chairman), Wellcome Trust (Committee Chairman), Institute of Cancer Research (Trustee) and University of Cologne/Bonn Center for Integrated Oncology (Scientific Advisory Board Member).

Appointed: October 1, 2012 Committee membership: Audit, Compliance & Risk Committee (Interim), Remuneration Committee and Science & Technology Committee Skills & experience: Steven brings to the Board his extensive technical and scientific knowledge and commercial experience. He is currently a Managing Director at ARCH Venture Partners; a provider of venture capital for technology firms. Prior to this Steven was a founder and Director of Corixa Corporation, acquired by GlaxoSmithKline in 2005, and before that a founder and Director of Immunex Corporation. An immunologist by training Steven has authored more than 300 peer-reviewed publications in the areas of molecular and tumor immunology. He is credited as being a pioneer in the field of cytokines and cytokine receptors, directing the development of multiple marketed products including Leukine, (GM-CSF), Prokine (IL-2) and Enbrel (soluble TNF receptor-Fc fusion protein) as well as the regulatory approval of Bexxar (radiolabeled anti-CD20) and the novel vaccine adjuvant, MPL. Steven received his BA from Williams College and his Ph.D. from Dartmouth College. Key appointments: ARCH Venture Partners (Managing Director), bluebird bio, Inc. (Non-Executive Director) and VBI Vaccines Inc. (Chairman and Non-Executive Director).

Appointed: June 16, 2010 Committee Chairmanship: Science & Technology Committee Skills & experience: David brings to the Board his clinical medical experience in internal medicine, hematology-oncology and medical genetics, as well as his extensive basic biomedical laboratory research expertise. David obtained his BA at Yale University, MD at Duke University and completed his medical and research training at Harvard Medical School. David is the recipient of numerous honors and awards, including election to membership in the National Academy of Sciences, the Institute of Medicine and the American Academy of Arts and Sciences. Key appointments: University of Michigan (James V. Neel Distinguished University Professor of Internal Medicine, Human Genetics and Pediatrics) and Howard Hughes Medical Institute (Investigator).

Appointed: September 1, 2015 Committee membership: Audit, Compliance & Risk Committee Skills & experience: Sara brings to the Board her financial, strategic and technological experience having held various corporate leadership roles. Until 2013 Sara served as Chairman, President and Chief Executive Officer of Dun & Bradstreet, Inc. having spent 12 years at the company. Prior to this, Sara worked for 18 years at Procter & Gamble where she held a variety of global finance and management positions including Vice President, Finance, Australia, Asia and India. Sara received her MBA from Xavier University, her Accounting degree from the Institute of Cost & Works Accountants and her Bachelor’s degree in Physics, Mathematics and Chemistry from the University of Madras. Key appointments: Avon Products, Inc. (Non-Executive Director), Campbell Soup Company (Non-Executive Director), Freddie Mac (Non-Executive Director) and Zurich Financial Services Group (International Advisory Council Member).

Appointed: June 16, 2010 Committee Chairmanship: Remuneration Committee Committee membership: Nomination Committee Skills & experience: Anne brings to the Board her extensive legal, commercial and remuneration experience. She held the position of Group Director, Human Resources at Centrica plc from 2002 to 2011 and was a member of the Centrica Executive Committee. Her extensive business career includes senior management roles at Shell UK, the position of Deputy Director-General of the Engineering Employers’ Federation and the position of Group Director Human Resources at Smiths Group plc. She is also a former Director of Northumbrian Water plc and SITA UK. Anne holds a Law degree and a postgraduate diploma in Human Resources, and is a qualified lawyer. She is also a Fellow of the Chartered Institute of Personnel & Development, the Royal Society of Arts and the London City and Guilds, and is a member of the Law Society of Scotland. Key appointments: Tate & Lyle PLC (Non-Executive Director), ExlService Holdings, Inc. (Non-Executive Director), University of Aberdeen Court (Non-Executive Director) and University of Aberdeen Development Trust (Vice Chairman and Trustee).